Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical
treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen
bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded
flexible structure. The effects of denaturation on RNA are similar though less pronounced
and largely reversible
Note générale sur le champ d'application :
IM general only; coord NIM with DNA or RNA or specific (IM)