A class of drugs that differs from other alkylating agents used clinically in that
they are monofunctional and thus unable to cross-link cellular macromolecules. Among
their common properties are a requirement for metabolic activation to intermediates
with antitumor efficacy and the presence in their chemical structures of N-methyl
groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms
by which each of these drugs acts to kill tumor cells are not completely understood.
(From AMA, Drug Evaluations Annual, 1994, p2026)
Point d'accès autorisé parallèle
Antineoplastic Agents, Alkylating
Identifiants externes
Identifiant MeSH : mesD018906
Utilisation dans FMeSH
Qualificatifs autorisés : IP / IM / PK / TU / BL / CF / CS / CH / UR / RE / HI / AN
/ CL / EC / PD / ST / AD / SD / PO / AE / TO / ME96
Informations sur la notice
Identifiant de la notice : 040834352
RCR créateur de la notice : 0001
Date de création : 23-09-1998
RCR dernier modificateur de la notice : 4994
Date de dernière modification : 26-11-2024 à 13 h 52