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Note publique d'information : After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory
RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly
to DNA binding proteins such as transcription factors that regulate gene expression
by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target
RNAs by interacting with specific sequences or RNA secondary structural features within
the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs
within target RNAs and which control the temporal, functional and spatial dynamics
of the target RNA define a putative “mRNP code”. These cis-regulatory RNA elements
can be found in the 5’ and 3’ untranslated regions (UTRs), introns, and exons of all
protein-coding genes. RNA elements in 5’ and 3’ UTRs are frequently involved in targeting
RNA to specific cellular compartments, affecting 3’ end formation, controlling RNA
stability and regulating mRNA translation. RNA elements in introns and exons are known
to function as splicing enhancers or silencers during the splicing process from pre-mRNA
to mature mRNA. This book provides case studies of RNA binding proteins that regulate
aspects of RNA processing that are important for fundamental understanding of diseases
and development. Chapters include systems-level perspectives, mechanistic insights
into RNA processing and RNA Binding proteins in genetic variation, development and
disease. The content focuses on systems biology and genomics of RNA Binding proteins
and their relation to human diseases
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