Identifiant pérenne de la notice : 208464565
Notice de type
Notice de regroupement
Note publique d'information : This book covers the tremendous progress in the current understanding of the molecular
physiology of voltage-gated calcium channels. This book includes unparalleled insights
into structural features of calcium channels due to X-ray crystallography and cryo-EM,
which in turn yielded critical information into how these channels function under
normal and pathophysiological conditions, and how they interact with calcium channel
therapeutics. The chapters investigate how, with the advent of high throughput genome
sequencing, numerous mutations in various calcium channel genes have been identified
in patients with neurological, cardiovascular, neuropsychiatric and other disorders.
This is further complemented through a much larger in vivo toolkit such as knock-out
and knock-in mice. The chapters further discuss the increased complexity of calcium
channel physiology that arises from mRNA editing and splicing. Finally, the book also
provides an overview of the updated research on calcium channel inhibitors that can
be used both in vivo and in vitro, and which may serve as a spring board for new calcium
channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for
academic researchers at all levels in neuroscience, biophysics, cell biology and drug
discovery. Provides a comprehensive update on the state of knowledge of voltage-gated
calcium channels; Examines how calcium channels are pharmacologic targets in the treatment
of epilepsy, hypertension, and pain; Explores the new, sophisticated imaging approaches
that have increased our ability to measure calcium in live cells; Presents an understanding
of the molecular mechanisms that govern calcium channel trafficking and distribution.
paprika.idref.fr
data.idref.fr
Documentation
