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Note publique d'information : Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits
telomerase activity, providing impetus for the development of G-quartet-interacting
drugs, while G-quartet-containing oligonucleotides have been recognized as a potent
class of aptamers effective against STAT3 and other transcription factors implicated
in oncogenesis, proving these guanine-quartets to be a vital and rich area for future
study. In G-Quadruplex DNA: Methods and Protocols, experts in the field present a
collection of detailed techniques for studying G-quartet formation, dynamics, and
molecular recognition. Written in the highly successful Methods in Molecular Biology™
series format, chapters include brief introductions to their respective topics, lists
of the necessary materials and reagents, step-by-step, readily reproducible laboratory
protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative
and cutting-edge, G-Quadruplex DNA: Methods and Protocols promises to be a useful
resource for those familiar with G-quartets as well as an easy entry point for those
researchers from diverse fields who are just developing an interest in the exciting
implications of G-quadruplex DNA
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