Identifiant pérenne de la notice : 215559924
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Note publique d'information : This volume details our current understanding of the architecture and signaling capabilities
of known canonical and non-canonical inflammasome complexes and highlights their action,
in particular in response to infection with important bacterial model organisms and
the corresponding disease pathologies. The first chapters review new insights into
the assembly and structures of inflammasome components and emphasize general strategies
of up- and downstream signaling events. In addition, the authors specifically discuss
the composition and activity of inflammasomes during infection with various gut pathogens
(Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens
(Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft
tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide
a better understanding of the cellular and molecular biology of inflammasomes, which
will pinpoint important new therapeutic targets for the treatment and prevention of
multiple infectious diseases in the future. It is a valuable resource for students,
scientists and clinicians, providing up-to-date information on this emerging research
topic
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