Identifiant pérenne de la notice : 211586676
Notice de type
Notice de regroupement
Note publique d'information : Atrial fibrillation (AF) is common and associated with significant morbidity, mortality
and important costs. Moderate efficacy and side effects of antiarhythmics drugs led
to the development of ablation techniques aiming directly left atrium’s underlying
substrate. Efficacy of cryoablation of pulmonary veins in patients with AF was several
times studied but its outcomes in the long term are unknown. We evaluated in a cohort
of patients, efficacy and safety of cryoablation of pulmonary veins in AF at 5 years.We
collected medical data from any adult patient who underwent AF cryoablation between
July 2007 and July 2015 in the Hôpital Louis Pradel, from patients’ hospital files.
Every patient was reached by survey or by phone to collect the outcomes. Cryoablation
efficacy was defined as AF recurrence-free survival and cryoablation safety defined
by overall survival without any adverse events (thromboembolic events, death), nor
procedures complications.Two hundred and forty-five patients were eligible and 221
were reached and included. Among them, 103 presented with atrial fibrillation recurrence.
There was a 52,4 +/- 4,2% probability of sinus rhythm maintenance at 5 years. No predictive
factor of recurrence was identified. Larger Body Mass Index and incomplete pulmonary
veins isolation tended to be predictive of AF recurrence. Regarding safety, 8 patients
suffered from stroke and 5 died. Probability of stroke at 5 years was 3,5 +/- 1,3%
and probability of death at five years was 3,5 +/- 1,7%. Procedural complications
were observed in 17,6% of the patients.Cryoablation of pulmonary veins allows in the
long-term maintenance of sinus rhythm in half of the patients treated. An aggressive
correction of risk factors of occurrence and progression of atrial myopathy, possible
arrhythmogenic AF substrate, is necessary to complement cryoablation to decrease AF
recurrences
paprika.idref.fr
data.idref.fr
Documentation
